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KMID : 0616120200510040231
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Korean Journal of Pharmacognosy
2020 Volume.51 No. 4 p.231 ~ p.237
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Inhibitory Effects of Euchrestaflavone B on Thrombus Formation via Regulation of Cyclic Nucleotides in Collagen-induced Platelets
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Kwon Hyuk-Woo
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Abstract
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Euchrestaflavanone B (EFB) is a flavonoid that can be found in root bark, particularly in Cudrania tricuspidata (C. tricuspidata). The extract of C. tricuspidata is widespread throughout Asia and used in traditional medicine. In a previous study, we found anti-platelet effects of substances isolated from C. tricuspidata on collagen-induced human platelets. However, the C. tricuspidata still contains numerous substances, thus, we have searched new candidate, EFB isolated from C. tricuspidata for anti-platelet effect. Our results showed that EFA inhibited collagen-induced platelet aggregation and glycoprotein IIb/IIIa (αIIb/β3)-mediated signaling events, including platelet adhesion, granule secretion, thromboxane A2 production and clot retraction. These results suggest that EFA has inhibitory effects on human platelet activities and thrombus formation and has potential value as a natural substance for preventing platelet-induced thrombosis.
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KEYWORD
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Euchrestaflavanone B, Glycoprotein IIb/IIIa, [Ca2+]i mobilization, Thromboxane A2, Clot retraction
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